Summary of Research
Tomatoes / Lycopene and Cardiovascular Risk Factors


In July 2006, a research database was constructed to manage the most up-to-date research describing the diet-disease relationship for tomatoes, tomato products and lycopene. This database was updated in 2007, 2009 and 2011.

In 2014, a modified update was performed focused on the clinical trial data assessing the relationship between lycopene supplementation or tomato intake on cardiovascular disease risk factors. This modified update includes the abstracts, citations, and endpoints of interest from clinical trials published in the peer-review literature with keys word searches including: tomato* and, or lycopene* and, lipids, cholesterol, blood pressure, oxidative stress, inflammation, endothelial function, and flow mediated dilation (FMD). There are 78 abstracts included in this update.

Endpoints of Interest Number of Clinical Trials in database

Blood Pressure – n=7

Lipids – n=25

Oxidative stress/ damage – n=62

Inflammation – n=14

Endothelial and Platelet function – n=12









Years covered: 1994-2014

Update provided Britt Burton-Freeman, PhD

Files: Six (6) sorted by date and first author:

  1. Complete database of all studies
  2. Blood Pressure
  3. Lipids
  4. Oxidative Stress/Damage
  5. Inflammation
  6. Endothelial and Platelet Function